Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease-Reference-Cited by-同舟云学术

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Published:2022-11-01 Issue:6 Volume:37 Page:311-322
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

O’Connell Timothy D.¹^ORCID,Murphy Katherine A.¹,Zhang Naixin¹,Puccini Sara J.¹,Healy Chastity L.¹,Harsch Brian A.²,Zhang Michael J.¹,Shearer Gregory C.²

Affiliation:

1. Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota

2. Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania

Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00007.2022

Reference147 articles.

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