The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model-Reference-Cited by-同舟云学术

The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model

Published:2015-07 Issue:4 Volume:30 Page:327-332
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Yosten Gina L. C.¹,Kolar Grant R.²

Affiliation:

1. Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, Missouri; and

2. Department of Pathology, St. Louis University School of Medicine, St. Louis, Missouri

Abstract

C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.

Funder

National Institutes of Health (FNIH)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00008.2015

Reference54 articles.

1. C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation

2. C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes

3. C-peptide and the risk for incident complications and mortality in type 2 diabetic patients: a retrospective cohort study after a 14-year follow-up