Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men’s Health-Reference-Cited by-同舟云学术

Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men’s Health

Published:2023-07-01 Issue:4 Volume:38 Page:161-166
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Sano Soichi¹²^ORCID,Thel Mark C.³,Walsh Kenneth³^ORCID

Affiliation:

1. Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan

2. Laboratory of Cardiovascular Mosaicism, National Cerebral and Cardiovascular Center, Osaka, Japan

3. Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States

Abstract

We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Kondou Kinen Medical Foundation

MSD Life Science Foundation, Public Interest Incorporated Foundation

Japan Society for the Promotion of Science

The Japanese Heart Failure Society

National Aeronautics and Space Administration

Novartis Foundation

Publisher

American Physiological Society

Subject