The Mechanobiology of Vascular Remodeling in the Aging Lung-Reference-Cited by-同舟云学术

The Mechanobiology of Vascular Remodeling in the Aging Lung

Published:2022-01-01 Issue:1 Volume:37 Page:28-38
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Dieffenbach Paul B.¹,Aravamudhan Aja²,Fredenburgh Laura E.¹,Tschumperlin Daniel J.²^ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

2. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota

Abstract

Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00019.2021

Reference158 articles.

1. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

2. Arterial Aging and Subclinical Arterial Disease are Fundamentally Intertwined at Macroscopic and Molecular Levels