Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation

Author:

Murach Kevin A.12,Fry Christopher S.3,Kirby Tyler J.4,Jackson Janna R.12,Lee Jonah D.5,White Sarah H.6,Dupont-Versteegden Esther E.12ORCID,McCarthy John J.17,Peterson Charlotte A.12

Affiliation:

1. The Center for Muscle Biology, University of Kentucky, Lexington, Kentucky

2. Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, Kentucky

3. Department of Nutrition and Metabolism, School of Health Professions, University of Texas Medical Branch at Galveston, Galveston, Texas

4. The Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York

5. Environment, Health, and Safety, University of Michigan, Ann Arbor, Michigan

6. Department of Animal Science, Texas A&M University, College Station, Texas

7. Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky

Abstract

Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

HHS | NIH | National Institute on Aging (U.S. National Institute on Aging)

HHS | NIH | National Center for Advancing Translational Sciences (NCATS)

Ellison Medical Foundation (EMF)

Publisher

American Physiological Society

Subject

Physiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3