Nondipping Blood Pressure: Predictive or Reactive Failure of Renal Sodium Handling?

Author:

Ivy Jessica R.1,Bailey Matthew A.1ORCID

Affiliation:

1. University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom

Abstract

Blood pressure follows a daily rhythm, dipping during nocturnal sleep in humans. Attenuation of this dip (nondipping) is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is essential for long-term blood pressure control. Sodium reabsorption and excretion have rhythms that rely on predictive/circadian as well as reactive adaptations. We explore how these rhythms might contribute to blood pressure rhythm in health and disease.

Funder

Kidney Research UK

Publisher

American Physiological Society

Subject

Physiology

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