Brain Glucose Sensing, Counterregulation, and Energy Homeostasis

Author:

Marty Nell12,Dallaporta Michel3,Thorens Bernard1

Affiliation:

1. Department of Physiology and Center for Integrative Genomics, Genopode Building, University of Lausanne, Lausanne, Switzerland;

2. Cellular Stress Group, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom; and

3. Laboratoire de Physiologie Neurovégétative, Université Paul Cézanne, Marseille, France

Abstract

Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.

Publisher

American Physiological Society

Subject

Physiology

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