NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers-Reference-Cited by-同舟云学术

NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

Published:2015-05 Issue:3 Volume:30 Page:241-250
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Claes Anne-Kathrin¹²³,Zhou Jun Yu¹,Philpott Dana J.¹

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, Ontario, Canada;

2. Division Models of Inflammation, Leibniz Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany; and

3. Institute for Experimental Medicine, University of Kiel, Kiel, Germany

Abstract

The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00025.2014

Reference119 articles.

1. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

2. NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

3. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

4. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition

5. GRIM-19 Interacts with Nucleotide Oligomerization Domain 2 and Serves as Downstream Effector of Anti-bacterial Function in Intestinal Epithelial Cells

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis;Frontiers in Cellular and Infection Microbiology;2024-04-26

2. Probiotics and their Beneficial Health Effects;Mini-Reviews in Medicinal Chemistry;2024-01

3. Altering the Gut Microbiome for Cognitive Benefit;The Gut-Brain Axis;2024

4. Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease;Biomedical Journal;2023-10

5. Genome-wide identification, phylogenetic relationships and expression patterns of the NOD-like receptor (NLR) gene family in flounder (Paralichthys olivaceus);Fish & Shellfish Immunology;2023-10