Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide-Reference-Cited by-同舟云学术

Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide

Published:2010-04 Issue:2 Volume:25 Page:64-71
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Perrotta Cristiana¹,Clementi Emilio¹²

Affiliation:

1. Unit of Clinical Pharmacology, Department of Preclinical Sciences, University Hospital “Luigi Sacco,” Università di Milano, Milano; and

2. E. Medea Scientific Institute, Bosisio Parini, Italy

Abstract

Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00048.2009

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