Mechanisms for the Resolution of Organ Fibrosis-Reference-Cited by-同舟云学术

Mechanisms for the Resolution of Organ Fibrosis

Published:2019-01-01 Issue:1 Volume:34 Page:43-55
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Horowitz Jeffrey C.¹,Thannickal Victor J.²

Affiliation:

1. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan

2. Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama

Abstract

Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function. Herein, we review mechanisms for resolution of organ fibrosis, in particular that involving the lung, with an emphasis on the critical roles of myofibroblast apoptosis and clearance of deposited matrix.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)

Health Services Research and Development (Veterans Health Administration HSR and D)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00033.2018

Reference195 articles.

1. Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis

2. X-Linked Inhibitor of Apoptosis Regulates Lung Fibroblast Resistance to Fas-Mediated Apoptosis