ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis-Reference-Cited by-同舟云学术

ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis

Published:2024-09-01 Issue:5 Volume:39 Page:324-344
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Zhang Lu¹,Feng Qianqian²,Kong Wei²^ORCID

Affiliation:

1. Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China

2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China

Abstract

Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.

Funder

MOST | National Key Research and Development Program of China

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00028.2023

Reference207 articles.

1. Epidemiology of cardiovascular disease in China: current features and implications

2. Atherosclerosis

3. Anti-inflammatory therapies for cardiovascular disease

4. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

5. Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Physiology in Perspective;Physiology;2024-09-01