Optogenetics: The Art of Illuminating Complex Signaling Pathways-Reference-Cited by-同舟云学术

Optogenetics: The Art of Illuminating Complex Signaling Pathways

Published:2021-01-01 Issue:1 Volume:36 Page:52-60
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Shaaya Mark¹,Fauser Jordan¹^ORCID,Karginov Andrei V.¹²

Affiliation:

1. Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, Illinois

2. University of Illinois Cancer Center, The University of Illinois at Chicago, Chicago, Illinois

Abstract

Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells. Optogenetic methods enable manipulation of signaling processes with precise timing and local control. In this review, we describe recent optogenetic approaches for regulation of cell signaling, highlight their advantages and limitations, and discuss examples of their application.

Funder

Chicago Biomedical Consortium

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00022.2020

Reference79 articles.

1. Light-activated protein interaction with high spatial subcellular confinement

2. Optogenetic control of signaling in mammalian cells

3. General Method for Regulating Protein Stability with Light

4. Optogenetics and the future of neuroscience

5. Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cryo-electron tomography of the actin cytoskeleton and membrane organization during lamellipodia formation using optogenetics;2024-08-14

2. Nano-optogenetics for Disease Therapies;ACS Nano;2024-05-20

3. Emerging optogenetics technologies in biomedical applications;Smart Medicine;2023-11

4. Modular Wavelength Adaptation of the Dynamic Optical MicroEnvironment;2023 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS);2023-10-09

5. Virtual stress plays tricks on cells;Cell Systems;2023-07