CNS Regulation of Glucose Homeostasis-Reference-Cited by-同舟云学术

CNS Regulation of Glucose Homeostasis

Published:2009-06 Issue:3 Volume:24 Page:159-170
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Lam Carol K. L.¹²,Chari Madhu¹²,Lam Tony K. T.¹²³

Affiliation:

1. Toronto General Research Institute, University Health Network, Toronto; and

2. Departments of Physiology and

3. Medicine, University of Toronto, Toronto, Canada

Abstract

The past decade has hosted a remarkable surge in research dedicated to the central control of homeostatic mechanisms. Evidence indicates that the brain, in particular the hypothalamus, directly senses hormones and nutrients to initiate behavioral and metabolic responses to control energy and nutrient homeostasis. Diabetes is chiefly characterized by hyperglycemia due to impaired glucose homeostatic regulation, and a primary therapeutic goal is to lower plasma glucose levels. As such, in this review, we highlight the role of the hypothalamus in the regulation of glucose homeostasis in particular and discuss the cellular and molecular mechanisms by which this neural pathway is orchestrated.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00003.2009

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