Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans-Reference-Cited by-同舟云学术

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

Published:2010-10 Issue:5 Volume:25 Page:272-279
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Taylor Cormac T.¹,McElwain Jennifer C.²

Affiliation:

1. UCD Conway Institute, Systems Biology Ireland and School of Medicine and Medical Science, and

2. UCD School of Biology and Environmental Sciences, University College Dublin, Belfield, Dublin, Ireland

Abstract

Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00029.2010

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