The Difference δ-Cells Make in Glucose Control-Reference-Cited by-同舟云学术

The Difference δ-Cells Make in Glucose Control

Published:2018-11-01 Issue:6 Volume:33 Page:403-411
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Huising Mark O.¹²,van der Meulen Talitha¹,Huang Jessica L.¹,Pourhosseinzadeh Mohammad S.¹,Noguchi Glyn M.¹

Affiliation:

1. Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California

2. Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California

Abstract

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Juvenile Diabetes Research Foundation International (JDRF)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00029.2018

Reference85 articles.

1. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets