Gaseous Modulators in the Control of the Hypothalamic Neurohypophyseal System

Author:

Ruginsk Silvia Graciela1,Mecawi Andre de Souza1,da Silva Melina Pires1,Reis Wagner Luis12,Coletti Ricardo1,Lima Juliana Bezerra Medeiros de1,Elias Lucila Leico Kagohara1,Antunes-Rodrigues Jose1

Affiliation:

1. Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil; and

2. Physiology Department, Georgia Regents University, Augusta, Georgia

Abstract

Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are gaseous molecules produced by the brain. Within the hypothalamus, gaseous molecules have been highlighted as autocrine and paracrine factors regulating endocrine function. Therefore, in the present review, we briefly discuss the main findings linking NO, CO, and H2S to the control of body fluid homeostasis at the hypothalamic level, with particular emphasis on the regulation of neurohypophyseal system output.

Publisher

American Physiological Society

Subject

Physiology

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