The Ins and Outs of Secretion from Pancreatic β-Cells: Control of Single-Vesicle Exo- and Endocytosis-Reference-Cited by-同舟云学术

The Ins and Outs of Secretion from Pancreatic β-Cells: Control of Single-Vesicle Exo- and Endocytosis

Published:2007-04 Issue:2 Volume:22 Page:113-121
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

MacDonald Patrick E.¹,Rorsman Patrik²

Affiliation:

1. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada; and

2. Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

Abstract

Exocytosis of insulin-containing secretory vesicles in pancreatic β-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in β-cells at the single-vesicle level.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00047.2006

Reference108 articles.

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3. The exocytotic event in chromaffin cells revealed by patch amperometry

4. Release of secretory products during transient vesicle fusion

5. Effects of Intravesicular H+ and Extracellular H+ and Zn2+ on Insulin Secretion in Pancreatic Beta Cells

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