Affiliation:
1. Department of Biomedicine, Aarhus University, Aarhus, Denmark
Abstract
The main findings of the current study are that area CA3 but not area CA1 can support 2-DG-induced seizure activity, that oxidative stress significantly contributes to 2-DG-induced seizure activity in area CA3, and that the impact of oxidative stress differs between synaptic and nonsynaptic epileptiform activity. In in vitro models where ictogenesis depends on synaptic interactions, oxidative stress lowers the seizure threshold, whereas in nonsynaptic models seizure threshold is unchanged or even increased.
Funder
AU | Sundhedsvidenskabelige Fakultet, Aarhus Universitet
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Cited by
1 articles.
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