Saline aerosol bolus dispersion. I. The effect of acinar airway alteration

Author:

Verbanck Sylvia1,Schuermans Daniël1,Vincken Walter1,Paiva Manuel2

Affiliation:

1. Respiratory Division, Academic Hospital, Vrije Universiteit Brussel, 1090 Brussels; and

2. Laboratoire de Physique Biomédicale, Université Libre de Bruxelles, 1070 Brussels, Belgium

Abstract

We explored the possibility of using a saline aerosol for bolus dispersion measurements to detect peripheral airway alterations in smokers. Indexes of ventilation inhomogeneity in conductive ( S cond) and acinar ( S acin) lung zones, as derived from the multiple-breath N2 washout (Verbanck S, Schuermans D, Van Muylem A, Noppen M, Paiva M, and Vincken W, J Appl Physiol 83: 1807–1816, 1997), were also measured. The saline bolus test consisted of inhaling 60-ml saline aerosol boluses to different volumetric lung depths (VLD) in the 1.1 liter volume above functional residual capacity. In the never-smoker group ( n = 12), saline boluses showed bolus dispersion values consistent with normal values reported in the literature for 0.5- to 1-μm aerosols. In the smoker group ( n = 12; 28 ± 9 pack years, mean ± SD), significant increases were seen on dispersion and skew of the most peripherally inhaled saline boluses (VLD = 800 ml; P < 0.05) as well as on S acin ( P = 0.007) with respect to never-smokers. Shallow inhaled boluses (VLD = 200 ml) and S cond did not reveal any significant differences between smokers and never-smokers. This study shows the consistent response of two conceptually independent tests, in which both saline aerosol and gas-derived indexes point to a heterogeneous distribution of smoking-induced structural alterations in the lung periphery.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3