Encoding of Amplitude and Rate of Tooth Loads by Human Periodontal Afferents From Premolar and Molar Teeth

Abstract

Microneurographic recordings were obtained from 20 periodontal mechanoreceptive afferents in the inferior alveolar nerve while force profiles of different amplitudes and rates were applied to a premolar or the first molar in the most sensitive direction. The majority of afferents (17/20) showed a hyperbolic relationship between the steady-state discharge rate and the amplitude of the stimulating force, featuring a pronounced saturation tendency. These afferents were also characterized by a similar decline in dynamic sensitivity with increasing amplitude of background force. However, a few afferents (3/20) showed nearly linear stimulus-response relationships and a small decline in dynamic sensitivity with increasing tooth load. Quantitative models developed for all afferents successfully predicted the afferent discharge rates for novel force stimulations. Application of the transfer function to chewing forces predicted that the discharge rates of periodontal afferents rapidly increased at initial tooth contact and continued to discharge as long as the tooth was loaded. However, due to the marked saturation tendencies at higher forces, most periodontal afferents poorly encoded the magnitude of the strong chewing forces. In addition, the discharge rates of a minority of afferents continued to reflect the force profile during high chewing forces. The results revealed that periodontal afferents of posterior teeth were less sensitive at low tooth loads compared with afferents of anterior teeth. During each chewing cycle, periodontal afferents may provide information about the mechanical properties of food shortly after tooth contact that can be used to scale the muscle commands of the upcoming power phase.