Activity in the pontine reticular nuclei scales with handgrip force in humans

Author:

Danielson Tyler L.1,Gould Layla A.2,DeFreitas Jason M.3ORCID,MacLennan Rob J.45ORCID,Ekstrand Chelsea6,Borowsky Ron7ORCID,Farthing Jonathan P.8,Andrushko Justin W.9ORCID

Affiliation:

1. Applied Neuromuscular Physiology Laboratory, College of Education and Human Sciences, Oklahoma State University, Stillwater, Oklahoma, United States

2. Division of Neurosurgery, Department of Surgery, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

3. Department of Exercise Science, Falk College of Sport and Human Dynamics, Syracuse University, Syracuse, New York, United States

4. Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida, United States

5. Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, Florida, United States

6. Department of Neuroscience, Faculty of Arts and Science, University of Lethbridge, Lethbridge, Alberta, Canada

7. Department of Psychology and Health Studies, College of Arts and Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

8. College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

9. Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom

Abstract

In this study, we used a task-based functional magnetic resonance imaging (fMRI) paradigm to show that activity in the pontine reticular nuclei scales linearly with increasing force during a handgrip task. These findings directly support recently proposed hypotheses that the reticulospinal tract may play an important role in modulating force production in humans.

Funder

Canadian Government | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

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