Modeling the effect of wall movement on absorption in the intestine

Author:

Macagno E. O.,Christensen J.,Lee C. L.

Abstract

Intestinal wall movements may influence intestinal absorption by inducing flow in the luminal volume. Direct evidence for this is scant and weak. Such evidence was sought by mechanical and analytical modeling. Wall motions resembling peristaltic ring contractions were induced in dialysis tubing filled with a concentrated salt solution and immersed in tap water. The disappearance of solute from the inside of the tube was monitored with conductivity probes and correlated with various kinds of wall motions. In analytical modeling, equations representing wall motions, flow, and mass transfer were constructed, with the assumptions that ring contractions are axisymmetric, the wall is totally compliant, the Reynolds' number is low, the fluid volume is conserved, the no-slip condition exists at the luminal surface, and inertial flow is negligible. In the mechanical model, wall motions caused a 30-35% increase in absorption that was matched in the corresponding analytical model. The analytical model demonstrated that the effect is progressively greater for nonpropagative stationary contractions, asymmetric progressive contractions, and symmetric progressive contractions, the increase being 33, 70, and 100%, respectively.

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

Cited by 34 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3