A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam
Author:
Affiliation:
1. Department of Neurology,
2. Graduate Program in Neuroscience, and
3. Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
Abstract
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Link
https://www.physiology.org/doi/pdf/10.1152/jn.00279.2011
Reference40 articles.
1. Benefit-Risk Assessment of Levetiracetam in the Treatment of Partial Seizures
2. Single synaptic vesicles fusing transiently and successively without loss of identity
3. Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission
4. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
5. SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis
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