Neural Coding Mechanisms for Flow Rate in Taste-Responsive Cells in the Nucleus of the Solitary Tract of the Rat

Abstract

When a taste stimulus enters the mouth, intentional movement of the stimulus within the oropharyngeal cavity affects the rate at which taste receptors are exposed to the stimulus and may ultimately affect taste perception. Early studies have shown that stimulus flow rate, the experimental equivalent of the effects of these investigative movements, modulates the portion of the peripheral nerve response that occurs when behavioral assessments of tastants are made. The present experiment studied the neural coding mechanisms for flow rate in the nucleus of the solitary tract (NTS), the first central relay in the taste pathway. Responses to NaCl (0.1 M) presented at high (5 ml/s) and low (3 ml/s) flow rates, sucrose (0.5 M), quinine HCl (0.01 M), and HCl (0.01 M) were recorded extracellularly from single NTS units in multiple replications. Information conveyed by evoked responses was analyzed with a family of metrics that quantify the similarity of two spike trains in terms of spike count and spike timing. Information about flow rate was conveyed by spike timing and spike count in approximately equal proportions of units (each ∼1/3), whereas information about taste quality was conveyed by spike timing in about half of the units. Different subsets of units contributed information for discrimination of flow rate and taste quality.