Affiliation:
1. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
Abstract
BK K+ channels are important regulators of firing. Although Ca2+ channels are required for their activation in excitable cells, it is not well understood how BK channels activate using these Ca2+ sources during an action potential. This study demonstrates the differences in BK current activated by CaV1.2 and CaV1.3 channels in clock neurons and heterologous cells. The results define how specific ion channel partnerships can be engaged during distinct phases of the action potential.
Funder
S & R Foundation/The American Physiological Society
HHS | NIH | National Heart, Lung, and Blood Institute
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases
HHS | NIH | National Institute of General Medical Sciences
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Cited by
6 articles.
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