Spinal cord neural activity of patients with fibromyalgia and healthy controls during temporal summation of pain: an fMRI study-Reference-Cited by-同舟云学术

Spinal cord neural activity of patients with fibromyalgia and healthy controls during temporal summation of pain: an fMRI study

Published:2021-09-01 Issue:3 Volume:126 Page:946-956
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Staud Roland¹^ORCID,Boissoneault Jeff²^ORCID,Lai Song³,Mejia Marlin S.¹,Ramanlal Riddhi¹,Godfrey Melyssa M.¹^ORCID,Stroman Patrick W.⁴^ORCID

Affiliation:

1. Department of Medicine, University of Florida, Gainesville, Florida

2. Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida

3. Department of Radiation Oncology, University of Florida, Gainesville, Florida

4. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

Abstract

“Windup” and its behavioral correlate “temporal-summation-of-second pain” (TSSP) represent spinal cord mechanisms of pain augmentation associated with central sensitization and chronic pain. Fibromyalgia (FM) is a chronic pain disorder, where abnormal TSSP has been demonstrated. We used fMRI to study spinal cord and brainstem activation during TSSP. We characterized the time course of spinal cord and brainstem BOLD activity during TSSP which showed abnormal brainstem activity in patients with FM, possibly due to deficient pain modulation.

Funder

UF | UF Health | College of Medicine, University of Florida

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00276.2021

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