Eupnea and gasping in vivo are facilitated by the activation of 5-HT2A receptors-Reference-Cited by-同舟云学术

Eupnea and gasping in vivo are facilitated by the activation of 5-HT2A receptors

Published:2021-05-01 Issue:5 Volume:125 Page:1543-1551
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Cummings Kevin J.¹^ORCID

Affiliation:

1. Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

Abstract

Previous in vitro studies suggest that 5-HT2A receptors contribute to eupnea and are necessary for fictive gasping. The current study shows that the impaired gasping displayed by neonatal TPH2−/− mice deficient in CNS serotonin is restored by a 5-HT2A receptor activation. Following 5-HT2A blockade, wild-type mice hypoventilated and their gasping resembled that of TPH2−/− mice. This study shows that both eupnea and gasping in vivo rely on the activation of 5-HT2A receptors.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00088.2021

Reference39 articles.

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3. Transgenic Mice Lacking Serotonin Neurons Have Severe Apnea and High Mortality during Development