The brain landscape of the two-hit model of posttraumatic stress disorder-Reference-Cited by-同舟云学术

The brain landscape of the two-hit model of posttraumatic stress disorder

Published:2022-12-01 Issue:6 Volume:128 Page:1617-1624
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

James Lisa M.¹²³⁴^ORCID,Engdahl Brian E.¹²⁴⁵,Christova Peka¹²⁴,Lewis Scott M.¹⁶,Georgopoulos Apostolos P.¹²³⁵⁶^ORCID

Affiliation:

1. The PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota

2. Department of Neuroscience, University of Minnesota Medical School, Minneapolis, Minnesota

3. Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota

4. Center for Cognitive Sciences, University of Minnesota, Minneapolis, Minnesota

5. Department of Psychology, University of Minnesota, Minneapolis, Minnesota

6. Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota

Abstract

The neurophysiological mechanisms underlying the development of PTSD are poorly understood. Here we document that massive engagement of sensory modalities during trauma exposure leads to fixed, hypercorrelated frontal, parietal, temporal, and limbic networks, reflecting the successive integration of salient sensory inputs along the framework of Jones and Powell.

Funder

U.S. Department of Veterans Affairs

University of Minnesota

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00340.2022

Reference48 articles.

1. Impaired safety signal learning may be a biomarker of PTSD

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3. Context Processing and the Neurobiology of Post-Traumatic Stress Disorder