Photic-Induced Sensitization: Acquisition of an Augmenting Spike-Wave Response in the Adult Rat Through Repeated Strobe Exposure

Abstract

It is well established that patterns of sensory input can affect neuroplastic changes during early development. The scope and consequences of experience-dependent plasticity in the adult are less well understood. We studied the possibility that repeated exposure to trains of stroboscopic stimuli could induce a sensitized and potentially aberrant response in ordinary individuals. Chronic electrocorticographic recording electrodes enabled measurement of responses in awake, freely moving animals. Normal adult rats, primarily Sprague-Dawley, were exposed to 20–40 strobe trains per day after a strobe-free adaptation period. The common response to strobe trains changed in 34/36 rats with development of a high-amplitude spike-wave response that emerged fully by the third day of photic exposure. Onset of this sensitized response was marked by short-term augmentation of response to successive strobe flashes. The waveform generalized across the brain, reflected characteristics of the visual stimulus, as well as an inherent 6- to 8-Hz pacing, and was suppressed with ethosuximide administration. Spike-wave episodes were self-limiting but could persist beyond the strobe period. Sensitization lasted 2–4 wk after last strobe exposure. The results indicate visual stimulation, by itself, can induce in adult rats an enduring sensitization of visual response with epileptiform characteristics. The results raise the question of the effects of such neuroplastic change on sensation and epileptiform events.