Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine

Author:

Matsa Elena1,Ahrens John H.1,Wu Joseph C.1

Affiliation:

1. Stanford Cardiovascular Institute, Department of Medicine, Division of Cardiology, and Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California

Abstract

Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug treatment. In this review, we describe how hiPSCs could transition cardiac healthcare away from simple disease diagnosis to prediction and prevention, bridging the gap between basic and clinical research to bring the best science to every patient.

Funder

American Heart Association (AHA)

Burroughs Wellcome Fund (BWF)

HHS | National Institutes of Health (NIH)

National Heart and Lung Institute (NHLI)

Stanford Cardiovascular Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Molecular Biology,Physiology,General Medicine

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