People with multiple sclerosis have reduced TMS-evoked motor cortical output compared with healthy individuals during fatiguing submaximal contractions-Reference-Cited by-同舟云学术

People with multiple sclerosis have reduced TMS-evoked motor cortical output compared with healthy individuals during fatiguing submaximal contractions

Published:2022-07-01 Issue:1 Volume:128 Page:105-117
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Brotherton Emily J.¹^ORCID,Sabapathy Surendran²^ORCID,Mckeown Daniel J.¹^ORCID,Kavanagh Justin J.¹^ORCID

Affiliation:

1. Neural Control of Movement Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

2. Exercise Physiology Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

Abstract

By combining TMS and motor nerve stimulation during a low-intensity exercise task, we were able to uncover the contribution that different levels of the CNS have during fatiguing exercise in PwMS. Our findings are novel and revealed that PwMS experienced decreased voluntary drive from the motor cortex during a low-intensity sustained fatiguing task that was associated with heightened levels of performance fatigability.

Funder

Griffith University

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00514.2021

Reference55 articles.

1. Motor cortex excitability and fatigue in multiple sclerosis: a transcranial magnetic stimulation study

2. Reduced Voluntary Activation During Brief and Sustained Contractions of a Hand Muscle in Secondary-Progressive Multiple Sclerosis Patients

3. Multiple sclerosis-related fatigue: the role of impaired corticospinal responses and heightened exercise fatigability

4. Central motor drive and perception of effort during fatigue in multiple sclerosis

5. The changing demographic pattern of multiple sclerosis epidemiology

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1. Short‐latency afferent inhibition is reduced in people with multiple sclerosis during fatiguing muscle contractions;European Journal of Neuroscience;2024-01-17

2. Voluntary muscle activation in people with multiple sclerosis is reduced across a wide range of forces following maximal effort-fatiguing contractions;Journal of Neurophysiology;2023-11-01

3. Neural bases of motor fatigue in multiple sclerosis: A multimodal approach using neuromuscular assessment and TMS-EEG;Neurobiology of Disease;2023-05

4. Voluntary muscle activation in people with Multiple Sclerosis is reduced across a wide range of forces following maximal effort fatiguing contractions;2023-04-28