Parental cardiorespiratory fitness influences early life energetics and metabolic health-Reference-Cited by-同舟云学术

Parental cardiorespiratory fitness influences early life energetics and metabolic health

Published:2024-02-01 Issue:2 Volume:56 Page:145-157
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Sadler Daniel G.¹²³^ORCID,Treas Lillie¹²,Ross Taylor¹²,Sikes James D.¹²,Britton Steven L.⁴,Koch Lauren G.⁵^ORCID,Piccolo Brian D.¹²³^ORCID,Børsheim Elisabet¹²³^ORCID,Porter Craig¹²³^ORCID

Affiliation:

1. Arkansas Children’s Nutrition Center, Little Rock, Arkansas, United States

2. Arkansas Children’s Research Institute, Little Rock, Arkansas, United States

3. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

4. Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States

5. Department of Physiology and Pharmacology, The University of Toledo, Toledo, Ohio, United States

Abstract

Inherited cardiorespiratory fitness (CRF) influences early life bioenergetics and metabolic health. Higher intrinsic CRF was associated with reduced adiposity and improved glucose tolerance in early life. This metabolic phenotype was accompanied by greater mitochondrial respiratory capacity in skeletal muscle, heart, and liver tissue. Proteomic profiling of these three tissues further revealed potential mechanisms linking inherited CRF to early life metabolism.

Funder

Arkansas Biosciences Institute

HHS | NIH | National Institute of General Medical Sciences

USDA | Agricultural Research Service

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00045.2023

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