Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer-Reference-Cited by-同舟云学术

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

Published:2024-02-01 Issue:2 Volume:56 Page:221-234
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Li Xiaoyi¹,Wu Dingfeng¹^ORCID,Li Qiuyu¹,Gu Jinglan¹,Gao Wenxing²,Zhu Xinyue²,Yin Wenjing²,Zhu Ruixin²,Zhu Lixin³^ORCID,Jiao Na¹^ORCID

Affiliation:

1. Department of Nephrology, Children’s Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China

2. The Shanghai Tenth People’s Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China

3. Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat‐sen University, Guangzhou, People’s Republic of China

Abstract

This study determined the following: 1) providing a comprehensive landscape of consensus molecular subtype (CMS)-specific tumor microenvironments (TMEs); 2) constructing CMS-specific networks, including host genes, intratumoral microbiota, and enriched pathways, analyzing their associations to uncover unique patterns that demonstrate the intricate interplay within the TME; and 3) revealing a connection between immune-rich subtypes and ferroptosis activation, suggesting a potential regulatory role of the microbiota in ferroptosis dysregulation of the colorectal cancer TME.

Funder

广东省人力资源和社会保障厅 | Guangdong Provincial Pearl River Talents Program

MOST | National Key Research and Development Program of China

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00103.2023

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