Rats in the genomic era

Author:

Worley K. C.1,Weinstock G. M.1,Gibbs R. A.1

Affiliation:

1. Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas

Abstract

The rat genome project and the resources that it has generated are transforming the translation of rat biology to human medicine. The rat genome was sequenced to a high quality “draft,” the structure and location of the genes were predicted, and a global assessment was published (Gibbs RA et al., Nature 428: 493–521, 2004). Since that time, researchers have made use of the genome sequence and annotations and related resources. We take this opportunity to review the currently available rat genome resources and to discuss the progress and future plans for the rat genome.

Publisher

American Physiological Society

Subject

Genetics,Physiology

Reference55 articles.

1. Aitman TJ, Gibbs RA, Weinstock GM, Hubner N, Jensen-Seaman MI, Maloney D, Jacob HJ. Proposal for discovering SNPs from eight commonly used inbred rat strains (http://www.genome.gov/Pages/Research/Sequencing/SeqProposals/RatSNPSeq.pdf).

2. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

3. Whole-genome re-sequencing

4. An intermediate grade of finished genomic sequence suitable for comparative analyses

5. Initial sequence of the chimpanzee genome and comparison with the human genome

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