The mitochondrial side of epigenetics

Author:

Castegna Alessandra12,Iacobazzi Vito123,Infantino Vittoria4

Affiliation:

1. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro,” Bari, Italy;

2. Center of Excellence in Comparative Genomics, University of Bari “Aldo Moro,” Bari, Italy;

3. CNR Institute of Biomembranes and Bioenergetics, Bari, Italy; and

4. Department of Sciences, University of Basilicata, Potenza, Italy

Abstract

The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much of their functionality, but their activities have been recently recognized to control nuclear gene expression as well as cell function in many different ways. Epigenetic mechanisms, which tune gene expression in response to environmental stimuli, are key regulatory events at the interplay between mitochondrial and nuclear interactions. Emerging findings indicate that epigenetic factors can be targets or instruments of mitochondrial-nuclear cross talk. Additionally, the growing interest into mtDNA epigenetic modifications opens new avenues into the interaction mechanisms between mitochondria and nucleus. In this review we summarize the points of mitochondrial and nuclear reciprocal control involving epigenetic factors, focusing on the role of mitochondrial genome and metabolism in shaping epigenetic modulation of gene expression. The relevance of the new findings on the methylation of mtDNA is also highlighted as a new frontier in the complex scenario of mitochondrial-nuclear communication.

Publisher

American Physiological Society

Subject

Genetics,Physiology

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