Affiliation:
1. Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
2. Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama
3. Department of Integrative Physiology, University of Colorado, Boulder, Colorado
Abstract
We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from ∼60 to ∼85% of AL body weight. This variation was not explained by the strain differences in absolute food intake, feces calorie content, motor activity, or AL body fat. Heritability was 40–50%, and several provisional quantitative trait loci were mapped. This variation can be used to test whether weight loss correlates with the health benefits of DR, independently of the reduction in calories. The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction.
Publisher
American Physiological Society
Reference29 articles.
1. Allison DB, Paultre F, Goran MI, Poehlman ET, and Heymsfield SB.Statistical considerations regarding the use of ratios to adjust data.Int J Obes Relat Metab Disord19: 644–652, 1995.
2. Bias in Estimates of Quantitative-Trait–Locus Effect in Genome Scans: Demonstration of the Phenomenon and a Method-of-Moments Procedure for Reducing Bias
3. Beavis WD.The power and deceit of QTL experiments: lessons from comparative QTL studies. In:49th Annual Corn and Sorghum Research Conference.Washington, DC: American Seed Trade Association, 1994, p. 250–266.
4. Changes in Adipose Mass and Cellularity Through the Adult Life of Rats Fed Ad Libitum or a Life-Prolonging Restricted Diet
5. Using mouse models to dissect the genetics of obesity
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献