Integrated miRNA-mRNA networks underlie attenuation of chronic β-adrenergic stimulation-induced cardiac remodeling by minocycline-Reference-Cited by-同舟云学术

Integrated miRNA-mRNA networks underlie attenuation of chronic β-adrenergic stimulation-induced cardiac remodeling by minocycline

Published:2024-04-01 Issue:4 Volume:56 Page:360-366
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Russell Jacob J.¹²,Mummidi Srinivas³,DeMarco Vincent G.²⁴,Grisanti Laurel A.¹^ORCID,Bailey Chastidy A.¹²,Bender Shawn B.¹²⁵^ORCID,Chandrasekar Bysani²⁴⁶⁵

Affiliation:

1. Biomedical Sciences, University of Missouri, Columbia, Missouri, United States

2. Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States

3. Health and Behavior Sciences, Texas A&M University-San Antonio, San Antonio, Texas, United States

4. Medicine, University of Missouri School of Medicine, Columbia, Missouri, United States

5. Dalton Cardiovascular Center, University of Missouri, Columbia, Missouri, United States

6. Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, United States

Abstract

We demonstrate that minocycline treatment prevents cardiac hypertrophy and fibrotic remodeling induced by chronic β-adrenergic stimulation by inducing antifibrotic shifts in the cardiac miRNA-mRNA transcriptome.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00140.2023

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