PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

Author:

Blond Martin Bæk1,Schnurr Theresia Maria2,Rosenkilde Mads1,Quist Jonas Salling1ORCID,Gram Anne Sofie1,Reichkendler Michala Holm13,Auerbach Pernille Landrock1,Nordby Pernille1,Skovgaard Lene Theil4,Ribel-Madsen Rasmus2,Justesen Johanne Marie2,Kilpeläinen Tuomas Oskari2,Ploug Thorkil1,Stallknecht Bente Merete1,Hansen Torben2

Affiliation:

1. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark

4. Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark

Abstract

The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5–7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.

Funder

University of Copenhagen (Københavns Universitet)

Gerda and Aage Haencshs Fond

Nordea Fonden

Ministry of science Technology and Innovation, Denmark

Novo Nordisk Foundation, Denmark

Else og Mogens Wedell Wedellsborgs Fond (Else and Mogens Wedell Wedellsborgs Fund)

Direktør Jacob Madsens og Hustru Olga Madsens Fond

Beckett-Fonden

Anna Bochardts Mindelegat

Oda og Hans Svenningsens Fond

A.P. Møller og hustru Chastine McKinney Møllers Familiefond

Det Frie Forskningsråd (Danish Council for Independent Research)

Publisher

American Physiological Society

Subject

Genetics,Physiology

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