Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones-Reference-Cited by-同舟云学术

Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones

Published:2024-02-01 Issue:2 Volume:56 Page:179-193
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Commodore Sarah¹,Ekpruke Carolyn Damilola¹^ORCID,Rousselle Dustin¹^ORCID,Alford Rachel¹,Babayev Maksat¹,Sharma Shikha¹^ORCID,Buechlein Aaron²,Rusch Douglas B.²,Silveyra Patricia¹^ORCID

Affiliation:

1. Department of Environmental and Occupational Health, School of Public Health, Indiana University Bloomington, Bloomington, Indiana, United States

2. Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, United States

Abstract

miRNAs play important roles in regulating gene and environmental interactions. However, their role in mediating sex differences in allergic responses and lung diseases has not been elucidated. Our study used a targeted omics approach to characterize the contributions of gonadal hormones and chromosomal components to lung responses to an allergen challenge. Our results point to the influence of sex hormones in miRNA expression and proinflammatory markers in allergic airway inflammation.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00049.2023

Reference44 articles.

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