Specific circulating miRNAs are associated with plasma lipids in a healthy American cohort-Reference-Cited by-同舟云学术

Specific circulating miRNAs are associated with plasma lipids in a healthy American cohort

Published:2024-07-01 Issue:7 Volume:56 Page:492-505
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Evans Levi W.¹,Durbin-Johnson Blythe²,Sutton Kristen J.³,Yam Phoebe³,Bouzid Yasmine Y.³,Cervantes Eduardo³,Bonnel Ellen³,Stephenson Charles B.¹³,Bennett Brian J.¹³^ORCID

Affiliation:

1. USDA-ARS-Western Human Nutrition Research Center, Davis, California, United States

2. Division of Biostatistics, University of California, Davis, California, United States

3. Department of Nutrition, University of California, Davis, California, United States

Abstract

This study explored the association between circulating microRNA (miRNA) and low-density lipoprotein cholesterol (LDL-c) in a healthy population of 353 participants. Two miRNAs, miR-15b-5p and miR-16-5p, were upregulated in individuals with at-risk LDL-c levels. Several miRNA clusters were positively and negatively correlated with LDL-c and are known to target mRNA involved in lipid metabolism. The study also investigated the influence of diet on circulating miRNA, suggesting potential biomarkers for hypercholesterolemia.

Funder

USDA | Agricultural Research Service

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00087.2023

Reference81 articles.

1. MicroRNAs

2. Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

3. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies

4. Serum MicroRNAs Are Promising Novel Biomarkers

5. Circulating microRNAs as novel biomarkers for diabetes mellitus