Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer-Reference-Cited by-同舟云学术

Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer

Published:2023-04-01 Issue:4 Volume:55 Page:168-178
ISSN:1094-8341
Container-title:Physiological Genomics
language:en
Short-container-title:Physiological Genomics

Author:

Suresh Karthik¹^ORCID,Del Rosario Othello¹,Kallem Medha¹,Singh Gayatri¹,Shah Anika¹,Zheng Linda¹,Yun Xin¹,Philip Nicolas M.¹,Putcha Nirupama¹,McClure Marni B.¹,Jiang Haiyang¹,D’Alessio Franco¹,Srivastava Meera²,Bera Alakesh²,Shimoda Larissa A.¹^ORCID,Merchant Michael³,Rane Madhavi J.³,Machamer Carolyn E.⁴,Mock Jason⁵^ORCID,Hagan Robert⁵^ORCID,Koch Abigail L.⁶,Punjabi Naresh M.⁶,Kolb Todd M.¹^ORCID,Damarla Mahendra¹^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

2. Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States

3. Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, United States

4. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

5. Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, United States

6. Department of Medicine, School of Medicine, University of Miami, Miami, Florida, United States

Abstract

MK2, known to promote caspase-3 nuclear translocation in the execution of apoptosis, is reduced in non-small cell lung cancer cells. In adenocarcinomas of patients, higher MK2 expression is associated with early-stage disease, better clinical response following chemotherapy and independently associated with improved survival.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Genetics,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00155.2022

Reference32 articles.

1. Chemotherapy Resistance in Lung Cancer

2. Apoptotic Signaling Pathways in Lung Cancer

3. Determinants of Response to the DNA Topoisomerase II Inhibitors Doxorubicin and Etoposide in Human Lung Cancer Cell Lines

4. Defective caspase-3 relocalization in non-small cell lung carcinoma

5. Mechanisms of caspase activation