Redundancy and multifunctionality among spinal locomotor networks

Author:

Pham Bau N.1ORCID,Luo Jiangyuan2ORCID,Anand Harnadar3,Kola Olivia2ORCID,Salcedo Pia4,Nguyen Connie5,Gaunt Sarah6,Zhong Hui7,Garfinkel Alan7,Tillakaratne Niranjala78,Edgerton V. Reggie7891011

Affiliation:

1. Department of Bioengineering, University of California, Los Angeles, California

2. Department of Neuroscience, University of California, Los Angeles, California

3. Institute for Society and Genetics, University of California, Los Angeles, California

4. Department of Psychobiology, University of California, Los Angeles, California

5. Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California

6. Department of Molecular Cellular and Developmental Biology, University of California, Los Angeles, California

7. Department of Integrative Biology and Physiology, University of California, Los Angeles, California

8. Brain Research Institute, University of California, Los Angeles, California

9. Department of Neurobiology, University of California, Los Angeles, California

10. Department of Neurosurgery, University of California, Los Angeles, California

11. Institut Guttmann, Hospital de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain

Abstract

The results are consistent with there being an extensive amount of redundancy among spinal locomotor circuits. Using the newly developed FosTRAP mouse model, only ∼20% of neurons that were active (labeled by fos-linked tdTomato expression) during a first bout of 30-min stepping were also labeled for c-fos during a second bout of stepping. This finding suggests variability of neural networks that enables selection of many combinations of neurons (synapses) when generating each step cycle.

Funder

NIH

Broccoli Foundation

Nanette and Burt Forester

PwC

Roberta Wilson

Be13ve in Miracles Foundation

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3