Redundancy and multifunctionality among spinal locomotor networks

Author:

Pham Bau N.1ORCID,Luo Jiangyuan2ORCID,Anand Harnadar3,Kola Olivia2ORCID,Salcedo Pia4,Nguyen Connie5,Gaunt Sarah6,Zhong Hui7,Garfinkel Alan7,Tillakaratne Niranjala78,Edgerton V. Reggie7891011

Affiliation:

1. Department of Bioengineering, University of California, Los Angeles, California

2. Department of Neuroscience, University of California, Los Angeles, California

3. Institute for Society and Genetics, University of California, Los Angeles, California

4. Department of Psychobiology, University of California, Los Angeles, California

5. Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California

6. Department of Molecular Cellular and Developmental Biology, University of California, Los Angeles, California

7. Department of Integrative Biology and Physiology, University of California, Los Angeles, California

8. Brain Research Institute, University of California, Los Angeles, California

9. Department of Neurobiology, University of California, Los Angeles, California

10. Department of Neurosurgery, University of California, Los Angeles, California

11. Institut Guttmann, Hospital de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain

Abstract

The results are consistent with there being an extensive amount of redundancy among spinal locomotor circuits. Using the newly developed FosTRAP mouse model, only ∼20% of neurons that were active (labeled by fos-linked tdTomato expression) during a first bout of 30-min stepping were also labeled for c-fos during a second bout of stepping. This finding suggests variability of neural networks that enables selection of many combinations of neurons (synapses) when generating each step cycle.

Funder

NIH

Broccoli Foundation

Nanette and Burt Forester

PwC

Roberta Wilson

Be13ve in Miracles Foundation

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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