Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice-Reference-Cited by-同舟云学术

Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice

Published:2023-12-01 Issue:6 Volume:130 Page:1578-1587
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Whitaker-Fornek Jessica R.¹²^ORCID,Jenkins Paul M.¹³^ORCID,Levitt Erica S.¹²⁴

Affiliation:

1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, United States

2. Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States

3. Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, United States

4. Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, United States

Abstract

Kölliker-Fuse (KF) neurons in acute brain slices from male Rett syndrome (RTT) mice receive reduced inhibitory synaptic inputs compared with wild-type littermates. In female RTT mice, inhibitory transmission was not different in KF neurons compared with controls. The results from this study show that sex-specific alterations in synaptic transmission occur in the KF of RTT mice.

Funder

HHS | NIH | National Institute of Mental Health

HHS | NIH | National Institute on Drug Abuse

International Rett Syndrome Foundation

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00327.2023

Reference50 articles.

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