A model of metabolic supply-demand mismatch leading to secondary brain injury-Reference-Cited by-同舟云学术

A model of metabolic supply-demand mismatch leading to secondary brain injury

Published:2021-08-01 Issue:2 Volume:126 Page:653-667
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Song Jiang-Ling¹²^ORCID,Kim Jennifer A.³,Struck Aaron F.⁴⁵^ORCID,Zhang Rui¹,Westover M. Brandon²

Affiliation:

1. The Medical Big Data Research Center, Northwest University, Xi’an, China

2. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

3. Department of Neurology, Yale New Haven Hospital, New Haven, Connecticut

4. Departments of Neurology, University of Wisconsin–Madison, Madison, Wisconsin

5. William S Middleton Veterans Administration Hospital, Madison, Wisconsin

Abstract

We present a novel mechanistic model for the metabolic supply demand mismatch hypothesis (MSDMH), which attempts to explain why patients with acute brain injury frequently develop seizure activity and secondary brain injury (SBI). Specifically, we investigate how decreased oxygen, increased extracellular potassium, excitotoxicity, seizures, all common sequalae of primary brain injury (PBI), can induce SBI and suggest three underlying paths for how events following PBI may lead to SBI.

Funder

Foundation for the National Institutes of Health

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00674.2020

Reference54 articles.

1. Mechanisms of Secondary Brain Damage in Global and Focal Ischemia: A Speculative Synthesis

2. Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study