TNF-α-activated eNOS signaling increases leukocyte adhesion through the S-nitrosylation pathway-Reference-Cited by-同舟云学术

TNF-α-activated eNOS signaling increases leukocyte adhesion through the S-nitrosylation pathway

Published:2021-12-01 Issue:6 Volume:321 Page:H1083-H1095
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Aguilar Gaynor¹,Córdova Francisco¹,Koning Tania¹,Sarmiento José²,Boric Mauricio P.³,Birukov Konstantin⁴^ORCID,Cancino Jorge⁵,Varas-Godoy Manuel⁵^ORCID,Soza Andrea⁵⁶,Alves Natascha G.⁷,Mujica Patricio E.⁷⁸^ORCID,Durán Walter N.⁷,Ehrenfeld Pamela⁹¹⁰^ORCID,Sánchez Fabiola A.¹¹⁰^ORCID

Affiliation:

1. Instituto de Inmunología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile

2. Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile

3. Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

4. Department of Anesthesiology, University of Maryland Baltimore School of Medicine, Baltimore, Maryland

5. Centro de Biología Celular y Biomedicina, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile

6. Facultad de Ciencias Biológicas, Centro de Envejecimiento y Regeneración, Pontificia Universidad Católica de Chile, Santiago, Chile

7. Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey

8. Department of Natural Sciences, School of Health and Natural Sciences, Mercy College, Dobbs Ferry, New York

9. Facultad de Medicina, Instituto de Anatomía, Histología y Patología, Universidad Austral de Chile, Valdivia, Chile

10. Centro Interdisciplinario de Estudios del Sistema Nervioso, Universidad Austral de Chile, Valdivia, Chile

Abstract

Contrary to the well-established inhibitory role of NO in leukocyte adhesion, we demonstrate a positive role of nitric oxide in this process. We demonstrate that NO induced by eNOS after TNF-α treatment induces early leukocyte adhesion activating the S-nitrosylation pathway. Our data suggest that PKCζ S-nitrosylation may be a key step in this process.

Funder

Fondequip

Programa de Apoyo a Centros con Financiamiento

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | NIH Office of the Director

MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico

Universidad Austral de Chile

Publisher

American Physiological Society

Subject