Affiliation:
1. Department of Psychology, Howell Hall, University of North Carolina, Chapel Hill, North Carolina
2. Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina
Abstract
Adaptive behavior in response to adverse experiences facilitates faster recovery and less time spent engaging in maladaptive behaviors that contribute to psychopathology, including anxiety, depression, and posttraumatic stress disorder. Dysregulation of activity in the prefrontal cortex (PFC) has been implicated in these disorders, with stress further exacerbating these negative effects. Corticotropin-releasing factor is an important regulator of the stress-response system and may have a differential involvement in individuals who are especially susceptible to negative stress-related outcomes. A recent study by Chen et al. (Chen P, Lou S, Huang ZH, Wang Z, Shan QH, Wang Y, Yang Y, Li X, Gong H, Jin Y, Zhang Z, Zhou Z. Neuron 106: 301–315, 2020) has identified a novel subtype of GABAergic CRF interneurons in the dorsomedial PFC that, upon activation, can promote active responses and resilient behavior in response to stress.
Funder
HHS | NIH | National Institute on Drug Abuse
HHS | NIH | National Institute on Alcohol Abuse and Alcoholism
Publisher
American Physiological Society
Subject
Physiology,General Neuroscience
Cited by
6 articles.
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