Interplay Between the Inspiratory and Postural Functions of the Human Parasternal Intercostal Muscles

Abstract

The parasternal intercostal muscles are obligatory inspiratory muscles. To test the hypothesis that they are also involved in trunk rotation and to assess the effect of any postural role on inspiratory drive to the muscles, intramuscular electromyographic (EMG) recordings were made from the parasternal intercostals on the right side in six healthy subjects during resting breathing in a neutral posture (“neutral breaths”), during an isometric axial rotation effort of the trunk to the right (“ipsilateral rotation”) or left (“contralateral rotation”), and during resting breathing with the trunk rotated. The parasternal intercostals were commonly active during ipsilateral rotation but were consistently silent during contralateral rotation. In addition, with ipsilateral rotation, peak parasternal inspiratory activity was 201 ± 19% (mean ± SE) of the peak inspiratory activity in neutral breaths ( P < 0.001), and activity commenced earlier relative to the onset of inspiratory flow. These changes resulted from an increase in the discharge frequency of motor units (14.3 ± 0.3 vs. 11.0 ± 0.3 Hz; P < 0.001) and the recruitment of new motor units. The majority of units that discharged during ipsilateral rotation were also active in inspiration. However, with contralateral rotation, parasternal inspiratory activity was delayed relative to the onset of inspiratory flow, and peak activity was reduced to 72 ± 4% of that in neutral breaths ( P < 0.001). This decrease resulted from a decrease in the inspiratory discharge frequency of units (10.5 ± 0.2 vs. 12.0 ± 0.2 Hz; P < 0.001) and the derecruitment of units. These observations confirm that in addition to an inspiratory function, the parasternal intercostal muscles have a postural function. Furthermore the postural and inspiratory drives depolarize the same motoneurons, and the postural contraction of the muscles alters their output during inspiration in a direction-dependent manner.