Coupling of sympathetic nerve traffic and BP at very low frequencies is mediated by large-amplitude events

Author:

Burgess Don E.12,Randall David C.324,Speakman Richard O.2,Brown David R.4

Affiliation:

1. Departments of Chemistry and Physics and

2. Department of Physiology, University of Kentucky College of Medicine, Lexington 40536-0298; and

3. Biology, Asbury College, Wilmore 40390-1198;

4. Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070

Abstract

This study explores the functional association between renal sympathetic nerve traffic (NT) and arterial blood pressure (BP) in the very-low-frequency range (i.e., <0.1 Hz). NT and BP ( n = 6) or BP alone ( n = 17) was recorded in unanesthetized rats ( n = 6). Data were collected for 2–5 h, and wavelet transforms were calculated from data epochs of up to 1 h. From these transforms, we obtained probability distributions for fluctuation amplitudes over a range of time scales. We also computed the cross-wavelet power spectrum between NT and BP to detect the occurrence in time of large-amplitude transient events that may be important in the autonomic regulation of BP. Finally, we computed a time sequence of cross correlations between NT and BP to follow the relationship between NT and BP in time. We found that NT and BP follow comparable self-similar scaling relationships (i.e., NT and BP fluctuations exhibit a certain type of power law behavior). Scaling of this nature 1) points to underlying dynamics over a wide range of scales and 2) is related to large-amplitude events that contribute to the very-low-frequency variability of NT and BP. There is a strong correlation between NT and BP during many of these transient events. These strong correlations and the uniformity in scaling imply a functional connection between these two signals at frequencies where we previously found no connection using spectral coherence.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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