Affiliation:
1. Section for Physiology and Cell Biology, Department of Biosciences, University of Oslo, Oslo, Norway
Abstract
We report a profound upregulation of most egln paralog mRNA levels in anoxia and upon reoxygenation, with egln3ii showing the largest, a 17-fold increase, and highest relative mRNA abundance. The relative abundance of prolyl hydroxylase domain (PHD) proteins was maintained during anoxia and increased at reoxygenation. PHD immunoreactivity was localized to axonal branches with region-specific changes during anoxia-reoxygenation. These dynamic and regional changes in crucian carp, champion of anoxia tolerance, are most likely adaptive and call for further mechanistic studies.
Funder
UiO:Life Science Convergence Environments
Research Council of Norway
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology