Abstract
Lesions of the amygdala have long been known to produce hyperphagia and obesity in cats, dogs, and monkeys, but only recently have studies with rats determined that the effective site is the posterodorsal amygdala (PDA)—the posterodorsal medial amygdaloid nucleus and the intra-amygdaloid bed nucleus of the stria terminalis. There is a sex difference; female rats with PDA lesions display greater weight gain than male rats. In the brains of female rats with obesity-inducing PDA lesions, there is a dense pattern of axonal degeneration in the capsule of the ventromedial hypothalamus (VMH) and other targets of the stria terminalis. Transections of the dorsal component of the stria terminalis also result in hyperphagia and obesity in female rats. Similar to rats with VMH lesions, rats with PDA lesions are hyperinsulinemic during food restriction and greatly prefer high-carbohydrate diets. The PDA is also a critical site for some aspects of rodent sexual behavior, particularly those that depend on olfaction, and the pattern of degeneration observed after obesity-inducing PDA lesions is remarkably parallel to the circuit that has been proposed to mediate sexual behavior. Medial amygdaloid lesions disrupt the normal feeding pattern and result in impaired responses to caloric challenges, and there is evidence that these behavioral changes are also due to a disruption of olfactory input. With its input from the olfactory bulbs and connections to the VMH, the PDA may be a nodal point at which olfactory and neuroendocrine stimuli are integrated to affect feeding behavior.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Reference236 articles.
1. Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta).
2. Differential effects of amygdaloid lesions on conditioned taste aversion learning by rats
3. Alajouanine T, Villey R, Nehlil J, and Houdart R. Troubles de l'appétit et rhinencéphalé, à propos plus particulièrement d'un cas régressif d'obésité par hyperphagie consécutif à une lobectomie temporale pour épilepsie. Presse Med 65: 1385–1387, 1957.
4. Alheid GF, de Olmos JS, and Beltramino CA. Amygdala and extended amygdala. In: The Rat Nervous System, edited by Paxinos G. San Diego, CA: Academic, 1995, p. 495–578.
5. FOOD INTAKE AND SPONTANEOUS ACTIVITY OF RATS WITH LESIONS IN THE AMYGDALOID NUCLEI
Cited by
51 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献